Selected Publications

  1. Qiu X, Macchietto M, Liu X, Lu Y, Ma Y, Guo H, Saqui-Salces M, Bernlohr DA, Chen C, Shen S, Chen X. Identification of gut microbiota and microbial metabolites regulated by an anti-microbial peptide lipocalin 2 in high fat dietinduced obesity. Int J Obes. 2020 (In press)
  2. Lin T, Guo H, Chen X. Pentraxin 3 Regulates miR-21 Expression and Secretion in Brown Adipocytes During Lipopolysaccharide-Induced Inflammation. Obesity  28(2):323-332, 2020
  3. Guo H, Qiu X, Deis J, Lin TY, Chen X. Pentraxin 3 deficiency exacerbates lipopolysaccharide-induced inflammation in adipose tissue. Int J Obes. 44(2):525-538, 2020.

  4. Xu Y, Zhu Y, Jadhav K, Li Y, Sun H, Yin L, Kasumov T, Chen X, Zhang Y. Lipocalin-2 Protects Against Diet-induced Non-alcoholic Fatty Liver Disease by Targeting Hepatocytes. Hepatol Commun 3(6):763-775, 2019.

  5. Deis JA, Guo H, Wu Y, Liu C, Bernlohr DA, Chen X. Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration. Mol Metab 24:18-29, 2019.

  6. Ran L, Wang X, Mi A, Liu Y, Wu J, Wang H, Guo M, Sun J, Liu B, Li Y, Wang D, Jiang R, Wang N, Gao W, Zeng L, Huang L, Chen X, LeRoith D, Liang B, Li X, Wu Y. Loss of Adipose GHR in Mice Enhances Local Fatty Acid Trapping and Impairs BAT Thermogenesis. iScience 16:106-121, 2019.

  7. Deis JA, Guo H, Wu Y, Liu C, Bernlohr DA, Chen X. Lipocalin 2 regulates retinoic acid-induced activation of beige adipocytes. J Mol Endocrinol 61(3):115-126, 2018.

  8. Qiu X, Guo H, Yang J, Ji Y, Wu CS, Chen X. Down-regulation of guanylate binding protein 1 causes mitochondrial dysfunction and cellular senescence in macrophages. Sci Rep 8(1):1679, 2018.

  9. Guo H, Zhao M, Qiu X, Deis JA, Huang H, Tang QQ, Chen X.   Niemann Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes.   J Lipid Res. 57(9): 1644-1658, 2016. 
  10. Chen SZ, Ning LF, Xu X, Jiang WY, Xing C, Jia WP, Chen XL,Tang QQ, Huang HY.   The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling.   Cell Death Differ 23(11): 1778-1791, 2016. 
  11. Guo H, Foncea R, O'Byrne SM, Jiang H, Zhang Y, Deis JA, Blaner WS, Bernlohr DA, Chen X.   Lipocalin 2: a regulator of retinoid homeostasis and retinoid-mediated thermogenic activation in adipose tissue.   Journal of Biological Chemistry 291(21): 11216–11229, 2016. 
  12. Zhao M and Chen X.   Effect of lipopolysaccharides on adipogenic potential and pre-mature senescence of adipocyte progenitors.   American Journal of Physiology - Endocrinology and Metabolism 309(4):334-44, 2015. 
  13. Brand LJ, Olson ME, Ravindranathan P, Guo H, Kempema AM, Andrews TE, Chen X, Raj GV, Harki DA, Dehm SM .   EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer.  Oncotarget 6(6):3811-24, 2015. 
  14. Guo H, Jin D, and Chen X.   Lipocalin 2 is a regulator of macrophage polarization and NF-kB/STAT3 pathway activation.  Molecular Endocrinology 28(10):1616-28, 2014. 
  15. Zhang Y, Guo H, Deis JA, Mashek MG, Zhao M, Ariyakumar D, Armien AG, Bernlohr DA, Mashek DG, and Chen X.   Lipocalin 2 regulates brown fat activation via a non-adrenergic activation mechanism.  Journal of Biological Chemistry 289(32):22063-77, 2014. 
  16. Brockman DA, Chen X and Gallaher DD.   High-Viscosity Dietary Fibers Reduce Adiposity and Decrease Hepatic Steatosis in Rats Fed a High-Fat Diet.  Journal of Nutrition 144(9):1415-22, 2014. 
  17. Zhao M and Chen X.   Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes.  Biochemical and Biophysical Research Communications 450(4):1446-51, 2014. 
  18. Zhang Y, Foncea R, Deis JA, Guo H, Bernlohr DA, and Chen X.   Lipocalin 2 expression and secretion is highly regulated by metabolic stress, cytokines, and nutrients in adipocytes.  PLoS One 9(5):e96997, 2014. 
  19. Friedlander NJ, Burhans MS, Ade L, O'Neill LM, Chen X and Ntambi JM.   Global deletion of lipocalin 2 does not reverse high-fat diet-induced obesity resistance in stearoyl-CoA desaturase-1 skin-specific knockout mice.  Biochemical and Biophysical Research Communications 445(3):578-583, 2014. 
  20. Guo H, Bazuine M, Jin D, Huang MM, Cushman SW, and Chen X.  Evidence for the regulatory role of lipocalin 2 in high-fat diet-induced adipose tissue remodeling in male mice.  Endocrinology 154(10):3525-3538, 2013. 
  21. Hannaford J, Guo H, and Chen X.  Involvement of cathepsins B and L in inflammation and cholesterol trafficking protein NPC2 secretion in macrophages.  Obesity 21(8):1586-95, 2013. 
  22. Brockman DA, Chen X and Gallaher DD.   Consumption of a high ß-glucan barley flour improves glucose control and fatty liver and increases muscle acylcarnitines in the Zucker diabetic fatty rat.  European Journal of Nutrition 52(7): 1743-1753, 2013. 
  23. Brockman DA, Chen X and Gallaher DD.   Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats.  Nutr Metab 9(1):100, 2012. 
  24. Guo H, Zhang Y, Hahn W, Brockman DA, Bernlohr DA, and Chen X.  Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice. Endocrinology 153(3):1183-1193, 2012. 
  25. Brockman DA and Chen X.   Proteomics in the characterization of adipose dysfunction in obesity.  Adipocyte 1(1):25-37, 2012.(Invited Review) 
  26. Jin D, Guo H, Bu SY, Zhang Y, Hannaford J, Mashek DG, and Chen X.   Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure.  FASEB J. 25(2):754-764, 2011. 
  27. Zhang Y and Chen X.   Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation.  American Journal of Physiology - Endocrinology and Metabolism 300(1):77-85, 2011. 
  28. Jin D, Zhang Y, and Chen X.   Lipocalin 2 deficiency inhibits cell proliferation, autophagy, and mitochondrial biogenesis in mouse embryonic cells.  Molecular and Cellular Biochemistry 351(1):165-172, 2011. 
  29. Guo H, Jin D, Zhang Y, Wright W, Bazuine M, Brockman DA, Bernlohr DA, and Chen X.  Lipocalin 2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice.  Diabetes 59(6):1376-1385, 2010. 
  30. Ding L, Jin D, and Chen X.  Luteolin Enhances Insulin Sensitivity via Activation of PPARgamma Transcriptional Activity in adipocytes.  Journal of Nutritional Biochemistry 21(10): 941-947, 2010.
  31. Wu Y, Sun H, Mejia W, Novosyadlyy R, Nunez N, Chen X, Mendoza A, Hong S, Khanna C, Brodt P, Yakar S.  IGF-1 regulates the liver microenvironment in obese mice and promotes liver metastasis.  Cancer Research 70(1):57-67, 2010.
  32. Chen X , Hunt D, Cushman SW, and Hess S.  Proteomic Characterization of Thiazolidindione Regulation of Obese Adipose Secretome in Zucker Obese Rats.  Proteomics - Clinical Applications 3(9):1099-1111, 2009.
  33. Zhang J, Wu YJ, Zhang Y, LeRoith D, Bernlohr DA, and Chen X.  The Role of Lipocalin 2 in the Regulation of Inflammation in Adipocytes and Macrophages. Molecular Endocrinology 22(6):1416-26, 2008.
  34. Chen X and Hess S. Adipose Proteome Analysis: the Focus on Mediators of Insulin Resistance. Expert Review of Proteomics 5(6):827-39, 2008.(Invited Review)
  35. Hess S and Chen X.  Applications of Proteomics to the Study of Adipose Tissue. In: Adipose Tissue Protocols, 2nd ed., Humana Press (2008).
  36. Zhang J, Wright W, Bernlohr DA, Cushman SW, and Chen X.  Alterations of the Classic Pathway of Complement in Adipose Tissue of Obesity and Insulin Resistance.  American Journal of Physiology - Endocrinology and Metabolism 292(5):1433-40, 2007.
  37. Xiang CC, Wu YJ, Ma L, Ding L, Lisinski I, Brownstein MJ, Cushman SW, and Chen X.  Characterization of Insulin Resistant Phenotype of Cultured Primary Rat Adipose Cells.   Diabetologia 50(5):1070-9, 2007.